CD1-restricted T-cell responses and microbial infection

CD1, a conserved family of major histocompatibility (MHC)-like glycoprotein s in mammals, specializes in capturing lipid rather than peptide antigen fo r presentation to T lymphocytes. The principles and mechanisms of this newl y discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new li pid-based microbial vaccines and adjuvants.