Age-related decline in striatal volume in monkeys as measured by magnetic resonance imaging

Age-related declines in striatal markers for the dopamine system have been demonstrated in several species. The current study investigated structural changes during aging in the rhesus monkey striatum. Male monkeys were studi ed using a volumetric spoiled gradient recall (SPGR) magnetic resonance ima ging protocol. The caudate nucleus and putamen were segmented by manual tra cing using landmarks made in the orthogonal planes. The whale brain volume (defined as volume of gray and white matter plus cerebrospinal fluid in ven tricles and sulci) was measured using a semi-automated algorithm. There was no correlation between age and whole brain volume. There were age-related declines in normalized (i.e. brain region/whole brain volume) caudate nucle us and putamen volumes. Monkeys in the young,group (n = 7, 39-45 months old ) had larger volumes of both the caudate nucleus and putamen than animals i n the middle-age (n = 5, 120-180 months) or old (it = 7, 291-360 months) gr oups. The current results provide normative data to assess potential interv entions (e.g. caloric restriction) in the aging process. (C) 2000 Elsevier Science Inc. All rights reserved.