The pathogenesis of AIDS-associated myelopathy is unknown. Elevated HIV-1 v
iral load in CSF has been associated with cognitive impairment. The authors
investigated if a similar association exists in patients with myelopathy,
The authors evaluated levels of HIV-1 RNA in the CSF of 16 individuals with
AIDS myelopathy and in 16 nonmyelopathic HIV-infected control subjects. Th
ere was no correlation between levels of HIV-1 RNA and the presence or seve
rity of myelopathy.