Striatal A(2A) adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats

Authors
Corsi, C Melani, A Bianchi, L Pedata, F
Citation
C. Corsi et al., Striatal A(2A) adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats, NEUROREPORT, 11(11), 2000, pp. 2591-2595
Citations number
25
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
11
Issue
11
Year of publication
2000
Pages
2591 - 2595
Database
ISI
SICI code
0959-4965(20000803)11:11<2591:SAARAD>2.0.ZU;2-D
Abstract
The effect of the adenosine A(2A) receptor antagonist SCH 58261 on glutamat e release was investigated in the striatum of young and old rats by microdi alysis experiments. SCH 58261 (50 nM) significantly decreased the spontaneo us and K+-evoked glutamate outflow in young rats. In aged rats, spontaneous glutamate outflow was significantly reduced in comparison to young rats an d SCH 58261 significantly increased spontaneous and K+-evoked glutamate out flow. It is suggested that the opposite effects of the A(2A) antagonist on glutamate outflow in young and aged rats can be respectively attributed to blockade of striatal A(2A) adenosine receptors located on glutamatergic ter minals and on the striatal indirect output pathway. NeuroReport 11:2591-259 5 (C) 2000 Lippincott Williams & Wilkins.