CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and H-3-mazindol and H-3-spiperone binding over 19 months

This study was designed to determine whether CuZn-superoxide dismutase (SOD ) is neuroprotective against aging in the nigrostriatal tract. Twenty-four male mice transgenic for human CuZnSOD, resulting in overexpression of the cytosolic enzyme, were compared with 11 matched controls over 19 months. Th ere was no difference in longevity, locomotor activity, or H-3-mazindol or H-3-spiperone binding in the nigrostriatal tract in the two groups. Thus th ere was no evidence that increased CuZnSOD was neuroprotective in this mode l. (C) 2000 Published by Elsevier Science Ireland Ltd.