Antitumoral action of 2-deoxy-D-glucose tetraacetate in human melanoma cells

The eater 2-deoxy-D-glucose tetraacetate (2-DOGTA) was recently shown to di splay cytostatic and cytotoxic activity in various lines of tumoral cells. In the present work, it was found to inhibit cell growth and confer chemose nsitivity to cisplatin in two lines of human melanoma cells, poorly respons ive to cisplatin. The inhibition of cell growth by 2-DOGTA was apparently n ot attributable to alteration of either D-glucose utilization or oxidation in these melanoma cell lines. In freshly isolated human melanoma cells, 2-D OGTA also inhibited cell growth, even in cells resistant to standard chemot herapeutic agents, such as temozolomide, cisplatin and/or vindesine. It is proposed, therefore, that 2-DOGTA should be further investigated for the tr eatment of melanoma patients, whether alone or in combination with known ch emotherapeutic agents.