Determination of absolute configurations of amines and amino acids using nonchiral derivatizing agents (NCDA) and deuterium NMR

[GRAPHICS] Enantiomeric analysis end empirical determination of the absolute configura tion of amines and amino acids can be easily performed using acetyl-d(3) ch loride as a nonchiral derivatizing agent (deuterium probe) and deuterium NM R in a chiral solvent (Courtieu's method), In the case of amino acids, deri vatization to amido esters, performed with methanol-d(4) and acetyl-d(3) ch loride, gives a double opportunity for enantiomeric analysis.