Facile, Fmoc-compatible solid-phase synthesis of peptide C-terminal thioesters

Authors
Swinnen, D Hilvert, D
Citation
D. Swinnen et D. Hilvert, Facile, Fmoc-compatible solid-phase synthesis of peptide C-terminal thioesters, ORG LETT, 2(16), 2000, pp. 2439-2442
Citations number
33
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
16
Year of publication
2000
Pages
2439 - 2442
Database
ISI
SICI code
1523-7060(20000810)2:16<2439:FFSSOP>2.0.ZU;2-V
Abstract
[GRAPHICS] A short route to peptide C terminal thioesters was developed that does not require the use of special linkers or resins and is compatible with standar d Fmoc chemistry, Following conventional solid phase peptide synthesis, an excess of Me2AlCl and EtSH in dichloromethane cleaves peptides from Wang or Pam resins to give the corresponding thioesters directly in good yield and purity.