Synthesis of enantiopure alpha,alpha-disubstituted amino acids from the asymmetric Strecker reaction products of aldehydes

Authors
Ma, DW Ding, K
Citation
Dw. Ma et K. Ding, Synthesis of enantiopure alpha,alpha-disubstituted amino acids from the asymmetric Strecker reaction products of aldehydes, ORG LETT, 2(16), 2000, pp. 2515-2517
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
16
Year of publication
2000
Pages
2515 - 2517
Database
ISI
SICI code
1523-7060(20000810)2:16<2515:SOEAAA>2.0.ZU;2-G
Abstract
[GRAPHICS] Treatment of the enolates of 4 generated from the asymmetric Strecker react ion products with alkyl halides or aldehydes provided the corresponding fun ctionalized products with high diastereoselectivity. Deprotection of these products afforded the corresponding enantiopure alpha,alpha-dialkyl amino a cids.