A short catalytic enantioselective synthesis of the proinflammatory eicosanoid 12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid (12(R)-HETE)

Authors
Han, XJ Corey, EJ
Citation
Xj. Han et Ej. Corey, A short catalytic enantioselective synthesis of the proinflammatory eicosanoid 12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid (12(R)-HETE), ORG LETT, 2(16), 2000, pp. 2543-2544
Citations number
41
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
16
Year of publication
2000
Pages
2543 - 2544
Database
ISI
SICI code
1523-7060(20000810)2:16<2543:ASCESO>2.0.ZU;2-J
Abstract
[GRAPHICS] A new and effective pathway is described for the synthesis of 12(R)-HETE an d the 12(S)-enantiomer from the common intermediates 4 and 8.