Membranous nephropathy with anti-tubular basement membrane antibody may beX-linked

The association of membranous nephropathy with Fanconi syndrome and anti-tu bular basement antibodies appears to be a distinct subset of familial membr anous nephropathy. We studied two Chinese families with four affected boys to evaluate the mode of inheritance of disease. HLA haplotype analysis of t he family members in these two pedigrees did not reveal any significant lin kages. However, microsatellite analysis of both pedigrees using markers on the X chromosome suggested linkage to the long arm of the X chromosome betw een the microsatellite markers DXS1001 and DXS1227, Identification and anal ysis of additional pedigrees may allow more precise mapping of the disease gene for anti-tubular basement membrane antibody-associated membranous neph ropathy.