Extrinsic allergic alveolitis occurs rarely in childhood. We present 5 case
s and briefly review the literature regarding this condition in the pediatr
ic population. This report includes all cases (n = 5) of extrinsic allergic
alveolitis known to have occurred in childhood on Malta. All cases were ma
les, and were initially misdiagnosed as having other respiratory illnesses
or mental disturbances. The diagnosis was based on a history of exposure to
birds, clinical findings, positive avian precipitins, a restrictive defect
on pulmonary function tests, and a suggestive chest X-ray appearance. All
were treated with high-dose oral steroids for 3-4 weeks, with excellent res
ponse. Although these patients appear to have suffered no long-term sequela
e, delayed diagnosis can lead to irreversible pulmonary fibrosis. The diagn
osis of extrinsic allergic alveolitis should be entertained early in the di
fferential diagnosis of children presenting with unusual respiratory sympto
ms and signs. (C) 2000 Wiley-Liss, Inc.