BIOTRANSFORMATION OF (-)-ISOPINOCAMPHEOL AND (-ISOPINOCAMPHEOL BY 3 FUNGI())

The biotransformation of (-)-isopinocampheol and (+)-isopinocampheol b y Glomerella cingulata has been studied. Both substrates were converte d to three pinanediols, respectively. The major metabolic products obt ained were diols. The main product of (-)-isopinocampheol was (1R, 2R, 3S, 4S, 5R)-3,4-pinanediol, and that of the (+)-enantiomer was (1S, 2 S, 3S, 5R, 7R)-3,7-pinanediol. These results confirmed that the oxidat ion by G. cingulata took place with enantioselectivity. In addition, t he same substrates were also converted by other fungi such as Rhizocto nia solani and Aspergillus niger. Some similarities exist between the main products of the metabolism of R. solani, while those of A. niger were somewhat different. (C) 1997 Elsevier Science Ltd. All rights res erved.