Hematopoietic stem cell transplantation. Experience at the Centro Medico Nacional de Occidente

Bone marrow transplantation has recently reached art special place as a the rapeutic tool, which was not available ten years ago. Aim and setting. Desc riptive information about the first fifteen cases transplanted at Centro Me dico Nacional de Occidente, on a third level attention in Guadalajara, Jali sco, Mexico. Material and methods. Fifteen patients were transplanted, were carried out autologous transplantation in ten patients and five have recei ved allogeneic transplant; one allogeneic transplant was performed with bon e marrow aspiration donor, all next donation were taken off from peripheral blood stem cell through apheresis procedures. From autologous transplant 3 with chronic myelogenous leukemia (CML), 3 with Hodgkin's disease, 2 with solid tumor, 1 with high risk acute myelogenous leukemia and 1 large and sm all cell lymphoma III-B stage. Received allogeneic transplant 4 patients wi th CML in chronic phase and one with acute lymphoblastic leukemia Ph +. Res ults. All patients grafted, the median time to achieve > 0.5 x 10(9)/L gran ulocytes was 14 days (range: 11-18) from autologous and 16 (range: 14-18) d ays from allogeneic transplant, whereas the median time to achieve > 20 x 1 0(9) /L platelets was 18 days (range: 15-35) from autologous and 22 days fr om allogeneic, three patients died into 100 days postprocedure, two allogen eic, from graft versus host disease III-IV degree, and one autologous from interstitial pneumonia, surviving patients have showed +30 days to + 1000 d ays survival. Conclusion. With these data we show that this procedure is in expensive, is factible and possible if it does coexist with multidisciplina ry and on time support, interest, dedication on, care, and enough informati on and desire to do it, including official decisions to perform and sponsor its continuity to the people who participate in it.