Stenotrophomonas maltophilia is frequently isolated from hospital environme
nts. In recent years, it has been reported that this bacterium is causing h
ospital infections at increasing rates and is gaining importance because of
its multiple resistance. Although it has been related to several infection
s, endocarditis caused by S, maltophilia is rarely encountered. In this cas
e stud!, endocarditis in a 40-y-old man with a history of aortic valve repl
acement is presented. Blood cultures revealed S. maltophilia to be the aeti
ological agent, which showed multiresistance to various antibiotics. Ticarc
illin-clavulanate and trimethoprim-sulfamethosazole were used in the treatm
ent.