Nitrite/nitrate (NOx) levels and hemodynamics during septic shock

Nitric oxide (NO) acts as a vasorelaxant. We investigated the relationship between nitrite/nitrate (NOx), which are the final metabolites of NO, and h emodynamics during septic shock. We also examined tumor necrosis factor alp ha (TNF-alpha), interleukin-8 (IL-8), and endotoxin. A significant negative correlation was observed between NOx levels and pulmonary capillary wedge pressure (PCWP; r = -0.6075, P = 0.0028). A significant positive correlatio n was noted between NOx levels and the cardiac index (CI; r = 0.5934, P = 0 .0038). A significant negative correlation was found between NOx levels and the systemic vascular resistance index (SVRI; r = -0.4354, P = 0.0485). A significant positive correlation was observed between NOx levels and the st roke volume index (SVI; r = 0.5040, P = 0.0186). A significantly close posi tive correlation was also observed between TNF-alpha levels and NOx levels (I = 0.7848, P < 0.0001). These findings suggest that NOx levels are closel y associated with hemodynamics during septic shock, resulting in a vascular relaxing effect.