Reductive methylation of secondary amines containing reducible, hydrolyzable and sterically hindered groups

Authors
Davis, BA Durden, DA
Citation
Ba. Davis et Da. Durden, Reductive methylation of secondary amines containing reducible, hydrolyzable and sterically hindered groups, SYN COMMUN, 30(18), 2000, pp. 3353-3362
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
30
Issue
18
Year of publication
2000
Pages
3353 - 3362
Database
ISI
SICI code
0039-7911(2000)30:18<3353:RMOSAC>2.0.ZU;2-J
Abstract
Aliphatic secondary amines, including those that are sterically hindered, u ndergo reductive methylation under mild conditions in high yield using form aldehyde and sodium phosphite solution without reducing or hydrolyzing ethy nyl, ester or cyano groups.