Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors

Authors
Overkleeft, HS Bos, PR Hekking, BG Gordon, EJ Ploegh, HL Kessler, BM
Citation
Hs. Overkleeft et al., Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors, TETRAHEDR L, 41(32), 2000, pp. 6005-6009
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
32
Year of publication
2000
Pages
6005 - 6009
Database
ISI
SICI code
0040-4039(20000805)41:32<6005:SPSOPV>2.0.ZU;2-T
Abstract
The solid phase synthesis of the known proteasome inhibitor ZL(3)VS, using Kenner's safety catch protocol, is described. This methodology has been ext ended to the synthesis of various novel peptide vinyl sulfone and peptide e poxyketone derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.