Merrilactone A, a novel neurotrophic sesquiterpene dilactone from Illiciummerrillianum

Authors
Huang, JM Yokoyama, R Yang, CS Fukuyama, Y
Citation
Jm. Huang et al., Merrilactone A, a novel neurotrophic sesquiterpene dilactone from Illiciummerrillianum, TETRAHEDR L, 41(32), 2000, pp. 6111-6114
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
32
Year of publication
2000
Pages
6111 - 6114
Database
ISI
SICI code
0040-4039(20000805)41:32<6111:MAANNS>2.0.ZU;2-1
Abstract
Merrilactone A, isolated from the pericarps of Illicium merrillianum, shows an intriguing neurotrophic activity in the cultures of fetal rat cortical neurons. Its structure has been elucidated to be a unique sesquiterpene bea ring two gamma-lactones and an oxetane ring by extensive analyses of spectr al data and then confirmed by X-ray crystallographic analysis. Further, the absolute configuration has been established by the modified Mosher's metho d. (C) 2000 Elsevier Science Ltd. All rights reserved.