Solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines

Authors
Berry, JM Howard, PW Thurston, DE
Citation
Jm. Berry et al., Solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines, TETRAHEDR L, 41(32), 2000, pp. 6171-6174
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
32
Year of publication
2000
Pages
6171 - 6174
Database
ISI
SICI code
0040-4039(20000805)41:32<6171:SSODP>2.0.ZU;2-M
Abstract
The solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazep ines (PBDs) on p-nitrophenyl carbonate Wang resin using a variety of oxidat ion/cyclisation procedures is reported. Final products can be released from the support in yields of up to 68% using TFA:CH2Cl2 (1:1). (C) 2000 Publis hed by Elsevier Science Ltd.