The solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazep
ines (PBDs) on p-nitrophenyl carbonate Wang resin using a variety of oxidat
ion/cyclisation procedures is reported. Final products can be released from
the support in yields of up to 68% using TFA:CH2Cl2 (1:1). (C) 2000 Publis
hed by Elsevier Science Ltd.