An efficient and extremely mild method for protecting alcohols as 2-tetrahydrofuranyl ethers

Authors
Barks, JM Gilbert, BC Parsons, AF Upeandran, B
Citation
Jm. Barks et al., An efficient and extremely mild method for protecting alcohols as 2-tetrahydrofuranyl ethers, TETRAHEDR L, 41(32), 2000, pp. 6249-6252
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
32
Year of publication
2000
Pages
6249 - 6252
Database
ISI
SICI code
0040-4039(20000805)41:32<6249:AEAEMM>2.0.ZU;2-T
Abstract
Reaction of primary or secondary alcohols with BrCCl3 and tetrahydrofuran, usually in the presence of 2,4,6-collidine, leads to the formation of 2-tet rahydrofuranyl ethers in good to excellent yield (56-92%). The reaction mec hanism is believed to involve a free-radical chain reaction. (C) 2000 Elsev ier Science Ltd. All rights reserved.