Preparation of an A-ring building block for the total synthesis of 1 alpha,25-dihydroxy vitamin D-3 and structurally related congeners: lipase-catalyzed stereoselective esterification of a suitable epoxyalcohol

Authors
Ferraboschi, P Reza-Elahi, S Scotti, L Santaniello, E
Citation
P. Ferraboschi et al., Preparation of an A-ring building block for the total synthesis of 1 alpha,25-dihydroxy vitamin D-3 and structurally related congeners: lipase-catalyzed stereoselective esterification of a suitable epoxyalcohol, TETRAHEDR-A, 11(13), 2000, pp. 2665-2668
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
13
Year of publication
2000
Pages
2665 - 2668
Database
ISI
SICI code
0957-4166(20000714)11:13<2665:POAABB>2.0.ZU;2-3
Abstract
An useful A-ring building block for the total synthesis of vitamin D-3 cong eners, compound 7, has been prepared starting from vitamin D-2 by a chemo-e nzymatic approach that relies on lipase-catalyzed acylation in an organic s olvent for the stereoselective step. (C) 2000 Elsevier Science Ltd. All rig hts reserved.