Absolute configuration of 2-methoxy-2-(2-naphthyl)propionic acid as determined by the H-1 NMR anisotropy method

Authors
Ichikawa, A Hiradate, S Sugio, A Kuwahara, S Watanabe, M Harada, N
Citation
A. Ichikawa et al., Absolute configuration of 2-methoxy-2-(2-naphthyl)propionic acid as determined by the H-1 NMR anisotropy method, TETRAHEDR-A, 11(13), 2000, pp. 2669-2675
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
13
Year of publication
2000
Pages
2669 - 2675
Database
ISI
SICI code
0957-4166(20000714)11:13<2669:ACO2AA>2.0.ZU;2-R
Abstract
2-Methoxy-2-(2-naphthyl)propionic acid 1 and 2-hydroxy-2-(2-naphthyl)propio nic acid 2 were prepared by the Grignard reaction of 2-naphthylmagnesium br omide with (1R,2S,5R)-(-)-menthyl pyruvate. The absolute configurations of (+)-1 and (+)-2 were determined to be S by the H-1 NMR anisotropy method. ( C) 2000 Elsevier Science Ltd. All rights reserved.