Resolution of racemic 1-azido-3-aryloxy-2-propanols by lipase-catalyzed enantioselective acetylation

Authors
Pchelka, BK Loupy, A Plenkiewicz, J Blanco, L
Citation
Bk. Pchelka et al., Resolution of racemic 1-azido-3-aryloxy-2-propanols by lipase-catalyzed enantioselective acetylation, TETRAHEDR-A, 11(13), 2000, pp. 2719-2732
Citations number
90
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
13
Year of publication
2000
Pages
2719 - 2732
Database
ISI
SICI code
0957-4166(20000714)11:13<2719:ROR1BL>2.0.ZU;2-S
Abstract
Kinetic resolution of racemic 1-azido-3-aryloxy-2-propanols la-g was perfor med using supported lipase of Candida antarctica-B (Novozym(R) SP 435) in t oluene at 4 degrees C with isopropenyl acetate as the acyl donor to afford the optically active (S)-alcohols 2a-g and their corresponding (R)-acetates 3a-g with E values from 56 to 72, (C) 2000 Elsevier Science Ltd. All right s reserved.