S. Attitallah et al., Similarities and/or dissimilarities of CYP2D6 polymorphism in three Tunisian ethnic groups: Arabs, Berbers, Numides, THERAPIE, 55(3), 2000, pp. 355-360
Using the validated probe drug debrisoquine and the 8 h urinary metabolic r
atio debrisoquine/4 hydroxy-debrisoquine, we have determined the phenotype
of the debrisoquine CYP2D6 dependent polymorphic metabolism in 464 Arabs, 2
27 Berbers and 215 Numides to elicit similarities or dissimilarities of poo
r metabolizer (PM) prevalence. We found 2.36 per cent of PM in Arabs, 3.08
per cent in Berbers and 2.33 per cent in Numides. These figures are similar
to those observed in Middle East populations, and cannot be considered as
different from those observed in Caucasians.