Two key chiral intermediates in a new 4-hydroxyisoleucine synthesis

Authors
Kassem, T Rolland, V Martinez, J Rolland, M
Citation
T. Kassem et al., Two key chiral intermediates in a new 4-hydroxyisoleucine synthesis, ACT CRYST C, 56, 2000, pp. 1037-1039
Citations number
9
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
ISSN journal
01082701 → ACNP
Volume
56
Year of publication
2000
Part
8
Pages
1037 - 1039
Database
ISI
SICI code
0108-2701(200008)56:<1037:TKCIIA>2.0.ZU;2-C
Abstract
We present the crystal and molecular structure of two key compounds of a ne w synthesis strategy for isomers of natural (2S,3R,4S)-4-hydroxyisoleucines , 2,3,5,6,7,8-hexahydro-3-(1-hydroxy-1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C16H23NO4, and 2,3,5,6,7,8-hexahydro- 3-(1-methyl-2-oxopropyl)-6,8-methano-7,7,8a-trimethyl-5H-1,4-benzoxazin-2-o ne, C16H23NO3. A new optically pure chiral oxazinone auxiliary derived from (1R,2R,5R)-2-hydroxypinan-3-one was used.