Social support and depression have been shown to affect the prognosis of co
ronary patients, and social support has been found to influence depression
in community and patient samples. We investigated the characteristics of co
ronary patients whose depressive symptomatology was most likely to improve
with social support, We predicted that social support would be most benefic
ial for the most severely depressed, the old, the poor, the most severely i
ll, and those with poor functional status, Patients (n = 590) with document
ed coronary artery disease were assessed for depressive symptoms, social su
pport, and functional status while in hospital. They were reassessed for de
pression 1 month later during a home visit. Depression scores were lower at
follow-up (p = 0.001), and improvement was more marked among those reporti
ng more support (p <0.001), The social support effect was strongest among t
hose with high levels of depression at baseline (p <0.001) and those with l
ower income (p = 0.01), Unexpectedly, social support was more strongly asso
ciated with improvement in younger patients (p = 0.01). Social support did
not interact with gender, disease severity, or functional status, These fin
dings are partially consistent with the notion that social support is most
effective for those who are most vulnerable and/or have few coping resource
s, These findings also have implications for the design and interpretation
of psychosocial interventions. (C)2000 by Excerpta Medico, Inc.