In decerebrate paralyzed cats, we examined the effects of two central motor
commands (fictive locomotion and scratching) on the discharge of dorsal ho
rn neurons receiving input from group III and IV tibial nerve afferents. We
recorded the impulse activity of 74 dorsal horn neurons, each of which rec
eived group III input from the tibial nerve. Electrical stimulation of the
mesencephalic locomotor region (MLR), which evoked fictive static contracti
on or fictive locomotion, inhibited the discharge of 44 of the 64 dorsal ho
rn neurons tested. The mean depth from the dorsal surface of the spinal cor
d of the 44 neurons whose discharge was inhibited by MLR stimulation was 1.
77 +/- 0.04 mm. Fictive scratching, evoked by topical application of bicucu
lline to the cervical spinal cord and irritation of the ear, inhibited the
discharge of 22 of the 29 dorsal horn neurons tested. Fourteen of the twent
y-two neurons whose discharge was inhibited by fictive scratching were foun
d to be inhibited by MLR stimulation as well. The mean depth from the dorsa
l surface of the cord of the 22 neurons whose discharge was inhibited by fi
ctive scratching was 1.77 +/- 0.06 mm. Stimulation of the MLR or the elicit
ation of fictive scratching had no effect on the activity of 22 dorsal horn
neurons receiving input from group III and IV tibial nerve afferents. The
mean depth from the dorsal surface of the cord was 1.17 +/- 0.07 mm, a valu
e that was significantly (P< 0.05) less than that for the neurons whose dis
charge was inhibited by either MLR stimulation or fictive scratching. We co
nclude that centrally evoked motor commands can inhibit the discharge of do
rsal horn neurons receiving thin fiber input from the periphery.