The artificial insemination (AI) industry has developed over the last 50 ye
ars to the extent that it is used in almost every country in the world. One
of the main factors contributing to its success is the confidence of the f
armers that germplasm is not associated with pathogens, so that Al can be p
erformed without risks. This has been achieved as a result of a considerabl
e amount of research based on sound scientific data that has identified the
major risk pathogens. A summary of these studies, given in this section, s
hows that despite the large number of agents that could be transmitted via
the semen, there are cost-effective means to prevent such hazards. One of t
he basic rules is that the males should be housed in strictly protected sem
en collection centres (SCCs). Such centres should be approved by the veteri
nary authorities based upon specific criteria, which include special housin
g and operating specifications. This also includes specific means of monito
ring the health of individual males through regular clinical examinations,
assessment of semen and testings for various diseases. Two new challenges c
an now be identified, one relevant to so-called emerging diseases the impac
t of which on the status of the semen donors should always be assessed, and
the second, relates to endangered genetic resources which may become extin
ct without active conservation programmes. The experience gained by the AI
industry over the last 50 years should help to solve those problems. Curren
tly, the use of semen derived from approved SCCs warrants their disease-fre
e status. (C) 2000 Elsevier Science B.V. All rights reserved.