Pharmaceuticals through enzymatic transesterification and enzymatic aminolysis reactions

Biotransformations are now accepted as a methodology for the preparation of fine chemicals. The majority of enzyme-catalysed reactions involve the use of hydrolases, especially lipases, in hydrolysis or transesterification re actions. Over the last few years, other interesting processes have appeared , not only with hydrolases but also with oxidoreductases and oxynitrilases. However, the use of lipases in organic solvents proves an excellent method ology for the preparation of single-isomer chiral drugs by enzymatic transe sterification and aminolysis reaction.