The natural product capsaicin inhibits photosynthetic electron transport at the reducing side of photosystem II and purple bacterial reaction center:structural details of capsaicin binding

Authors
Spyridaki, A Fritzsch, G Kouimtzoglou, E Baciou, L Ghanotakis, D
Citation
A. Spyridaki et al., The natural product capsaicin inhibits photosynthetic electron transport at the reducing side of photosystem II and purple bacterial reaction center:structural details of capsaicin binding, BBA-BIOENER, 1459(1), 2000, pp. 69-76
Citations number
31
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
ISSN journal
00052728 → ACNP
Volume
1459
Issue
1
Year of publication
2000
Pages
69 - 76
Database
ISI
SICI code
0005-2728(20000720)1459:1<69:TNPCIP>2.0.ZU;2-X
Abstract
Capsaicin, a natural quinone analog, was found to block electron transport, in both plant photosystem II (PSII) and bacterial reaction center (RC) fro m Rhodobacter sphaeroides, at the Q(B) site. The mode of action of capsaici n was investigated by O-2 evolution measurements and fluoresence induction studies in the case of PSII, and flash-induced absorbance spectroscopy in t he case of the bacterial RC. Structural details of capsaicin binding to the bacterial RC complex were determined by X-ray crystallographic analysis. ( C) 2000 Elsevier Science B.V. All rights reserved.