Total synthesis of 16-desmethylepothilone B, epothilone B-10 epothilone F,and related side chain modified epothilone B analogues

The macrolactonization-based strategy for the total synthesis of epothilone s has been streamlined and improved to a high level of efficiency and stere oselectivity, This strategy has been applied to the construction of vinyl i odide 19 which served as a common intermediate for the synthesis of a serie s of natural and designed epothilones including an epothilone B-10 (3), epo thilone F (5), 16-desmethylepothilone B (14), pyridine epothilones 57a-57g, dimeric epothilones 59 and 61, and benzenoid epothilones 63a-63g.