New advances in the discovery of thrombin and factor Xa inhibitors

Authors
Citation
Jp. Vacca, New advances in the discovery of thrombin and factor Xa inhibitors, CURR OP C B, 4(4), 2000, pp. 394-400
Citations number
39
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
4
Issue
4
Year of publication
2000
Pages
394 - 400
Database
ISI
SICI code
1367-5931(200008)4:4<394:NAITDO>2.0.ZU;2-W
Abstract
The search for the ideal anticoagulant has spanned decades and has resulted in several strategies including the clinical use of heparin, low molecular weight heparins, and the vitamin K antagonist warfarin. Over the past five years, many groups have reported preclinical results with direct-acting th rombin inhibitors and several of these are now moving into clinical trials. In addition, many groups have disclosed the discovery of potent, orally bi oavailable factor Xa inhibitors. Several of these compounds are now in earl y clinical trials and the results are forthcoming.