Bradykinin antagonists: new opportunities

Citation
Mg. Bock et J. Longmore, Bradykinin antagonists: new opportunities, CURR OP C B, 4(4), 2000, pp. 401-406
Citations number
37
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
4
Issue
4
Year of publication
2000
Pages
401 - 406
Database
ISI
SICI code
1367-5931(200008)4:4<401:BANO>2.0.ZU;2-K
Abstract
The pro-inflammatory, pain producing, and cardiovascular effects of bradyki nin B-2 receptor activation are well characterized. Bradykinin B-1 receptor s also produce inflammation and pain. Therefore, antagonists are expected t o be anti-inflammatory/analgesic drugs. Other exploitable clinical opportun ities may exist. The newly discovered non-peptide B-2 receptor antagonists and the equivalent B-1 receptor pharmacological agents, which are in the pi peline, are suitable preclinical tools to properly evaluate potential utili ties.