Synthesis of interleukin 1 beta and interleukin 6 by stimulated rat peritoneal macrophages: Modulation by glutamine

Authors
Yassad, A Husson, A Bion, A Lavoinne, A
Citation
A. Yassad et al., Synthesis of interleukin 1 beta and interleukin 6 by stimulated rat peritoneal macrophages: Modulation by glutamine, CYTOKINE, 12(8), 2000, pp. 1288-1291
Citations number
12
Categorie Soggetti
Cell & Developmental Biology
Journal title
CYTOKINE
ISSN journal
10434666 → ACNP
Volume
12
Issue
8
Year of publication
2000
Pages
1288 - 1291
Database
ISI
SICI code
1043-4666(200008)12:8<1288:SOI1BA>2.0.ZU;2-E
Abstract
Synthesis and secretion of IL-1 beta and IL-6 were compared in LPS-stimulat ed rat peritoneal macrophages, and the effect of glutamine studied. LPS ind uced a parallel increase in mRNA and synthesis of IL-1 beta and IL-6, IL-1 beta accumulated mainly in the cytosol and IL-6 in the culture medium. Glut amine addition increased the synthesis of both cytokines, but the overall p roduction (intra- + extracellular) of IL-1 beta increased two-fold, althoug h that of IL-6 increased only 1.3-fold. The influence of glutamine is discu ssed. (C) 2000 Academic Press.