Is local excision adequate therapy for early rectal cancer?

PURPOSE: Radical surgery of rectal cancer is associated with significant mo rbidity, and some patients with low-lying lesions must accept a permanent c olostomy. Several studies have suggested satisfactory tumor control after l ocal excision of early rectal cancer. The purpose of this study was to comp are recurrence and survival rates after treating early rectal cancers with local excision and radical surgery. METHODS: One hundred eight patients wit h T1 and T2 rectal adenocarcinomas treated by transanal excision were compa red with 153 patients with T1N0 and T2N0 rectal adenocarcinomas treated wit h radical surgery. Neither group received adjuvant chemoradiation. Mean fol low-up time was 4.4 years after local excision and 4.8 years after radical surgery. RESULTS: The estimated five-year local recurrence rate was 28 perc ent (18 percent for T1 tumors and 47 percent for T2 tumors) after local exc ision and 4 percent (none for TI tumors and 6 percent for T2 tumors) after radical surgery. Overall recurrence was also higher after local excision (2 1 percent for T1 tumors and 47 percent for T2 tumors) than after radical su rgery (9 percent for T1 tumors and 16 percent for T2 tumors). Twenty-four o f 27 patients with recurrence after local excision underwent salvage surger y. The estimated five-year overall survival rate was 69 percent after local excision (72 percent for T1 tumors and 65 percent after T2 tumors) and 82 percent after radical surgery (80 percent for T1 tumors and 81 percent for T2 tumors). Differences in survival rate between local excision and radical surgery were statistically significant in patients with T2 tumors. CONCLUS IONS: Local excision of early rectal cancer carries a high risk of local re currence. Salvage surgery is possible in most patients with local recurrenc e, but may be effective only in patients with T1 tumors. When compared with radical surgery, local excision may compromise overall survival in patient s with T2 rectal cancers.