SCRAM: A scoring and ranking system for persistent, bioaccumulative, and toxic substances for the North American Great Lakes part III. Acute and subchronic or chronic toxicity

In Parr I of this series (SNYDER et al., 1999a), the Chemical Scoring and R anking Assessment Model (SCRAM) was introduced. This system produces scores for chemicals based on their bioaccumulation potential, environmental pers istence, and toxicity. In Part II, scoring of the potential for a chemical to persist in the environment and bioaccumulate was described (SNYDER et al ., 1999b). In Part III, scoring of chemical toxicity is discussed, includin g definitions and descriptions of effects that are scored, specific scoring instructions, the basis for the criteria and scores, and specific conditio ns or concerns regarding the types of data used for scoring. A score for ea ch chemical screened is determined from available test data from acute or s ubchronic and chronic toxicity tests conducted on aquatic and terrestrial o rganisms. Subchronic and chronic human health effects, including carcinogen icity, are also considered. Part TV includes an evaluation of the performan ce of the scoring and ranking system (SNYDER et al., 1999c).