F. Takeuchi et al., ASSOCIATION OF DM GENES IN SYSTEMIC-SCLEROSIS IS SECONDARY TO THE ASSOCIATION WITH HLA GENES, Scandinavian journal of rheumatology, 26(3), 1997, pp. 174-179
The contribution of polymorphism of DMA and DMB alleles to the pathoge
nesis of Japanese Systemic Sclerosis (SSc) was studied in 55 Japanese
SSc patients and 77 normal Japanese subjects using the PCR-RFLP (restr
iction fragment length polymorphism) method. The allele frequencies of
DMB0101 allele were increased in SSc with diffuse scleroderma (70.0%
vs 49.4%, p<0.05, pc=not significant (NS)) and in SSc with antitopois
omerase I antibody (a-Scl-70), (68.2%, p<0.05, pc=NS). The phenotype f
requencies of DMB0101 in these subgroups of SSc were increased signif
icantly (95.0%, p=0.014, pc<0.05; 95.5%, p=0.0088, pc<0.05, respective
ly). In contrast, DMB0102 and DMB*0103 alleles tended to decrease in
diffuse scleroderma and SSc with a-Scl-70, but the decreases were not
significant. Association analysis among DMA, DMB, and DRB11502 in Jap
anese SSc with diffuse scleroderma and SSc with a-Scl-70 indicated tha
t the increase in DMA0101 was not primary, but reflected an increase
in KLA DRB11502.