M. Jeffers et al., NON-HODGKINS-LYMPHOMAS COMPLICATING SJOGRENS-SYNDROME - CAN EPSTEIN-BARR-VIRUS BE IMPLICATED, Scandinavian journal of rheumatology, 26(3), 1997, pp. 180-183
We examined eight (6 parotid, 1 caecum, 1 lymph node) non Hodgkin's Ly
mphomas (NHL) complicating primary Sjogren's syndrome (SS), four parot
id NHL, in patients without SS, and three salivary gland biopsies from
SS patients and no NHL, for Epstein Barr virus (EBV), using immunohis
tochemistry for late membrane protein, in situ hybridisation (ISH) for
EBER, and PCR for EBV DNA. Late membrane protein was not detected. In
NHL's complicating SS, EBERs were detected in two parotid lymphomas b
y ISH. EBV DNA was detected in three SS parotid NHL. Cecal and lymph n
ode SS NHL were negative for EBER and EBV DNA. EBV DNA was detected in
two non SS NHLs, one expressed EBER. Despite positive EBV DNA results
by PCR in three samples expression of EBER was noted in only one by I
SH. This was a high grade NHL complicating SS. There was no evidence o
f EBV in low grade NHLs complicating SS.