Decline of life's energy theory of ageing 1. Revitalisation of energy metabolism and ageing mitochondria

This article discusses the decline in mitochondrial energy production capab ility that occurs as animals age. Correlation is made between age-related m itochondrial functionality decline, lower growth hormone (GH) secretion and declining mitochondrial component levels and the chronic wasting condition s that arise as a consequence. During the past few years a number of patent s have bren issued tl-lat have: utilised compositions containing the nutrac euticals carnitine, acetyl carnitine and their derivatives to therapeutical ly treat problems of energy metabolism. The administration of carnitine der ivatives will improve the quality of living during the period of life when the body's energy declines. The significance of the patented therapeutic us e of carnitine derivatives to re-establish mitochondrial functionality and its relationship to the ageing process are reviewed.