ADAM-TS/metallospondin genes encode a new family of proteins with structura
l homology to the ADAM metalloprotease-disintegrin family. However, unlike
other ADAMs, these proteins contain thrombospondin type 1 (TSP1) repeats at
the carboxy-terminal end and are secreted proteins instead of being membra
ne bound. Members of the ADAM-TS family have been implicated in the cleavag
e of proteoglycans, the control of organ shape during development, and the
inhibition of angiogenesis, We have cloned a new member of the ADAM-TS/meta
llospondin family designated here as ADAMTS9, This protein has a metallopro
tease domain, a disintegrin-like domain, one internal TSP1 motif, and three
carboxy-terminal TSP1-like submotifs, Tn contrast; to other ADAM-TS family
members, ADAMTS9 is expressed in all fetal tissues examined as well as som
e adult tissues. Using FISH and radiation hybrid analysis, we have localize
d ADAMTS9 to chromosome 3p14.2-p14.3, an area known to be lost in hereditar
y renal tumors. (C) 2000 Academic Press.