New salts of N-substituted piracetam

Authors
Pernak, J Drygas, J
Citation
J. Pernak et J. Drygas, New salts of N-substituted piracetam, IND ENG RES, 39(8), 2000, pp. 2761-2765
Citations number
20
Categorie Soggetti
Chemical Engineering
Journal title
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
ISSN journal
08885885 → ACNP
Volume
39
Issue
8
Year of publication
2000
Pages
2761 - 2765
Database
ISI
SICI code
0888-5885(200008)39:8<2761:NSONP>2.0.ZU;2-B
Abstract
Methyl (2-oxo-1-pyrrolidinyl)acetate reacts with (aminomethyl)pyridines wit h the elimination of methanol to form (2-oxo-1-pyrrolidiny1)(N-pyridinylmet hyl)acetamide which, quaternized smoothly by ROCH2Cl, gives the new salts o f N-substituted piracetam. Both steps occur in high yields. The obtained py ridinium chlorides showed antielectrostatic properties, which depend on a c arbon chain in alkoxymethyl substituent and bactericidal and fungicidal act ivity.