Transient plasma human immunodeficiency virus (HIV) copies were detected by
nucleic-acid sequence-based amplification during combination antiretrovira
l prophylaxis in a healthcare worker who reported a percutaneous injury fro
m a stylet and who remained HIV-antibody-negative. An HIV-specific T-helper
response, assessed by interleukin-2 production, was observed when tested a
t 13 months following the exposure (Infect Control Hosp Epidemiol 2000;21:5
29-531).