The propionate of heme binds N4O2 Schiff base antimalarial drug complexes

Schiff base N4O2 complexes offer a flexible template on which to develop no vel antimalarial drug complexes that inhibit the aggregation of hemozoin, a detoxification product of the malaria parasite Plasmodium falciparum. The efficacies of these complexes are dependent on the charges of the complexes . Further evidence suggests that these complexes inhibit hemozoin formation via a specific drug/heme propionate salt that prevents the formation of th e requisite axial propionato linkage in the repeating dimeric unit of the h emozoin aggregate. [GRAPHICS]