Decontamination of a Mycoplasma-infected Chlamydia pneumoniae strain by pulmonary passage in SCID mice

Authors
Essig, A Heinemann, M Schweitzer, R Simnacher, U Marre, R
Citation
A. Essig et al., Decontamination of a Mycoplasma-infected Chlamydia pneumoniae strain by pulmonary passage in SCID mice, INT J MED M, 290(3), 2000, pp. 289-292
Citations number
14
Categorie Soggetti
Microbiology
Journal title
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
ISSN journal
14384221 → ACNP
Volume
290
Issue
3
Year of publication
2000
Pages
289 - 292
Database
ISI
SICI code
1438-4221(200007)290:3<289:DOAMCP>2.0.ZU;2-X
Abstract
We describe a procedure to eliminate contaminating Mycoplasma from Chlamydi a pneumoniae (C. pneumoniae) cultures by pulmonary passage in severe combin ed immunodeficiency mice (SCID). Four weeks after experimental infection on ly C. pneumoniae could be cultured from the lungs of the infected animals w hile Mycoplasma could not be detected any longer, as shown by PCR, culture and transmission electron microscopy (TEM).