Dengue infection presenting with central nervous system manifestation

The objective of this study was to investigate the possibility of dengue vi rus infection causing an abnormal neurologic presentation. Between 1996 and 1998, all pediatric patients with clinical manifestations of encephalitis- like illness who were admitted to the Department of Pediatrics, Siriraj Hos pital were prospectively studied for any evidence of dengue virus infection . The diagnosis of dengue virus infection was based on mosquito viral isola tion and serologic and polymerase chain reaction (PCR) evidence. Of 44 pati ents with the preliminary diagnosis of acute viral encephalitis, 8 were dia gnosed with dengue infection. All of these 8 patients were diagnosed by ser ology. In addition to the serologic diagnosis, four also had positive PCR, one had positive viral isolation, and one had both positive PCR and viral i solation. Only two patients were diagnosed by serologic evidence alone. All except one had clinical courses and laboratory findings compatible with ty pical dengue infection. All had obvious encephalitic clinical manifestation s with normal cerebrospinal fluid findings except one patient, who had mild ly increased cerebrospinal fluid protein. All of these patients recovered c ompletely and had benign clinical courses except one patient, who developed leakage symptoms. None had liver failure. Dengue virus can cause acute enc ephalopathy with fever. It can masquerade as other types of acute viral enc ephalitis. However its clinical course and prognosis are usually favorable.