Association between patient-related factors and risk of calcium oxalate and magnesium ammonium phosphate urolithiasis in cats

Objective-To determine whether breed, age, sex, or reproductive status lie, neutered versus sexually intact) was associated with the apparent increase in prevalence of calcium oxalate (CaOx) uroliths and the decrease in preva lence of magnesium ammonium phosphate (MAP) uroliths in cats over time. Design-Case-control study. Animals-Case cats consisted of cats with CaOx (n = 7,8951 or MAP (7,334) ur oliths evaluated at the Minnesota Urolith Center between 1981 and 1997. Con trol cats consisted of cats without urinary tract disease admitted to veter inary leaching hospitals in the United States and Canada during the same pe riod (150,482). Procedure-Univariate and multivariate logistic regression were performed. Results-British Shorthair, Exotic Shorthair, Foreign Shorthair, Havana Brow n, Himalayan, Persian, Ragdoll, and Scottish Fold cats had an increased ris k of developing CaOx uroliths, as did male cats and neutered cats. Chartreu x, domestic shorthair, Foreign Shorthair, Himalayan, Oriental Shorthair, an d Ragdoll cats had an increased risk of developing MAP uroliths, as did fem ale cats and neutered cats. Cats with CaOx uroliths were significantly olde r than cats with MAP uroliths. Conclusions and Clinical Relevance-Results suggest that changes in breed, a ge, sex, or reproductive status did not contribute to the apparent reciproc al relationship between prevalences of CaOx and MAP uroliths in cats during a 17-year period. However, cats of particular breeds, ages, sex, and repro ductive status had an increased risk of developing CaOx and MAP uroliths.