Jj. Zhang et al., A superoxide dismutase mimic with high activity: crystal structure, solution equilibrium and pulse radiolysis, J CHEM S DA, (12), 2000, pp. 1893-1900
Citations number
62
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
A new binuclear copper(II) complex [Cu-2(H(-4)tapt)]. 10H(2)O, where tapt i
s N,N',N ",N'''-tetra(2-aminopropyl)-1,1,2,2-ethanetetraamide, has been syn
thesized and investigated in detail as a mimic of superoxide dismutase. Cry
stal structure analysis shows that each copper atom is situated in a slight
ly distorted square-pyramidal environment, with a water molecule at the ape
x. According to the result of pulse radiolysis, the complex has a high rate
constant toward O-.(2)-, k(cat)=1.91x10(8) dm(3) mol(-1) s(-1) (pH 7.4). P
otentiometric titration shows that the mimic exhibits high stability at phy
siological pH value (7.4). EPR and ES-MS spectra reveal intermolecular inte
raction of two copper(II) nuclei.