The co-ordination behaviours of two dipeptides, glycyl-aspartic acid (Gly-A
sp) and aspartyl-glycine (Asp-Gly), towards dimethyltin(IV) cations have be
en investigated by potentiometry and spectroscopic methods (H-1 and C-13 NM
R and Mossbauer). The formation of mononuclear complexes has been detected
between pH 2 and 10, although the hydrolysed species are also present in th
e solution. On the basis of pH-metric and NMR data, the carboxylate groups
are bound to the metal ion in the acidic pH range and act as anchoring grou
ps for the metal-promoted deprotonation of amide nitrogens between pH 4 and
7. The complexes formed in this way are relatively inert on the NMR timesc
ale in the case of both ligands, allowing their structural characterization
by NMR spectroscopy. These species can be described with a trigonal bipyra
midal structure having a {CO2-, N-amide(-), NH2} co-ordination, where the m
etal-bound carboxylate is very likely the C-terminal one. In spite of the c
onstitutional differences, Asp-Gly and Gly-Asp form stable complexes with d
imethyltin(IV) cation in the neutral pH range with identical structure and
geometry.