Synthetic studies on the pederin family of antitumour agents. Syntheses ofmycalamide B, theopederin D and pederin

Authors
Kocienski, P Narquizian, R Raubo, P Smith, C Farrugia, LJ Muir, K Boyle, FT
Citation
P. Kocienski et al., Synthetic studies on the pederin family of antitumour agents. Syntheses ofmycalamide B, theopederin D and pederin, J CHEM S P1, (15), 2000, pp. 2357-2384
Citations number
91
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14704358 → ACNP
Issue
15
Year of publication
2000
Pages
2357 - 2384
Database
ISI
SICI code
1470-4358(2000):15<2357:SSOTPF>2.0.ZU;2-X
Abstract
A general modular approach to the members of the pederin family of antitumo ur agents is exemplified by syntheses of mycalamide B and theopederin D as well as a formal synthesis of pederin. All three compounds are prepared fro m 6-lithio-2,3-dimethyl-4-phenylselenomethyl-3,4-dihydro-2H-pyran and 2-(3- chloropropyl)-3,3-dimethyl-3,4-dihydro-2H-pyran-4-one.